Substituted aminoalkoxybenzene derivatives

Details Substituted aminoalkoxybenzene derivatives Substituted aminoalkoxybenzene derivatives

C - Chemistry, Metallurgy

07

C

167/179, 260/578

C07C 225/16 (2006.01) A61K 31/135 (2006.01) A61K 31/395 (2006.01) C07C 217/18 (2006.01) C07C 217/20 (2006.01) C07C 217/22 (2006.01) C07C 217/46 (2006.01) C07C 255/59 (2006.01) C07D 205/04 (2006.01) C07D 295/092 (2006.01) C07D 295/112 (2006.01)

Patent

CA 2020888

RAN 4450/53 Abstract The compounds of the formula Image I wherein R1 and R2 each signify hydrogen, lower alkyl or lower alkenyl or together signify straight- -chain alkylene with 2 to 4 carbon atoms, R3 signifies hydrogen, halogen or lower alkyl, Q signifies alkylene or alkenylene with 4 to 11 carbon atoms and at least 4 carbon atoms between the two free valencies and Y and Y' each signify a direct bond or the group -CH2-, -CH2CH2-, -CH=CH- or -C?C-, the group R1R2N-Q-O- is attached to the 3- or 4-position of the ring denoted by A and the symbol R signifies that the ring is unsubstituted or is mono- or multiply-substituted by halogen, trifluoromethyl, cyano, nitro, lower alkyl and/or lower alkoxy, and their pharmaceutically acceptable acid addition salts can be used for the control or prevention of fungal infections, especially of topical or systemic infections which are caused by pathogenic fungi, and for the manufacture of antifungally-active medicaments. The compounds of formula I have not only a pronounced antifungal activity, but they also exhibit synergistic effects in combination with other known antifungally- -active substances which inhibit sterol biosynthesis such as ketoconazole and terbinafin.

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