Indenyl hydroxamic acids and hydroxy ureas as inhibitors of...

C - Chemistry – Metallurgy – 07 – C

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167/207, 167/264

C07C 317/50 (2006.01) A61K 31/16 (2006.01) C07C 323/63 (2006.01)

Patent

CA 2007786

Compounds having the formula I: (see formula I) are inhibitors of the 5-lipoxygenase enzyme. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine.

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