Multiple sclerosis virus

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/48 (2006.01) C07H 21/00 (2006.01) C07K 2/00 (2006.01) C07K 4/02 (2006.01) C07K 14/15 (2006.01) C12Q 1/70 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2163641

The present invention provides a polynucleotide in substantially isolated form comprising a sequence of nucleotides which is capable of selectively hybridizing to the genome of the human multiple sclerosis virus (HMSV) or the complement thereof, wherein HMSV is characterized by: (i) a positive stranded RNA genome; (ii) said genome comprising one or more open reading frames (ORF) encoding protein(s) or polyproteins(s); (iii) said genome encoding a reverse transcriptase enzyme; and (iv) said genome comprising nucleotide sequences which are homologous to or selectively hybridizable with any one of the nucleotide sequences illustrated in Seq. ID Nos. 1 to 6.

La présente invention se rapporte à un polynucléotide se présentant sous une forme sensiblement isolée comprenant une séquence nucléotidique apte à hybrider sélectivement le génome du virus de la sclérose en plaques humaine (HMSV) ou son complément, le HMSV étant caractérisé par: (i) un génome d'ARN à brins positifs, (ii) ce génome comprenant un ou plusieurs cadres ouverts de lecture (ORF) codant une ou des protéines ou polyprotéines; (iii) ce génome codant une transcriptase inverse; et (iv) ce génome comprenant des séquences nucléotidiques homologues ou sélectivement hybridables à n'importe laquelle des séquences nucléotidiques représentées par les numéros d'identification de séquence 1 à 6.

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