C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/10 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) C07D 239/95 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 405/10 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07D 487/10 (2006.01) C07D 491/107 (2006.01)
Patent
CA 2714087
The instant invention provides for compounds which comprise substituted thioquinazolinones that inhibit CHK1 activity. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting CHK1 activity by administering the compound to a patient in need of treatment of cancer.
La présente invention concerne des composés contenant des thioquinazolinones substituées qui inhibent lactivité de CHK1. Linvention concerne également des compositions contenant de tels composés inhibiteurs et des méthodes dinhibition de lactivité de CHK1 par ladministration du composé à un patient ayant besoin dêtre traité pour un cancer.
Converso Antonella
Garbaccio Robert M.
Hartingh Timothy J.
Kreatsoulas Constantine
Rickert Keith W.
Gowling Lafleur Henderson Llp
Merck Sharp & Dohme Corp.
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