Prostate-restricted gene 30p3c8 expressed in prostate cancer

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 13/08 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 14/81 (2006.01) C07K 16/18 (2006.01) C12N 15/62 (2006.01) C12N 15/87 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2369384

A gene (designated 30P3C8) and its encoded protein is described. 30P3C8 exhibits restricted tissue expression in normal adult tissue and is overexpressed in prostate tissue xenografts, providing evidence that it is aberrantly expressed in at least some prostate cancers. Consequently, 30P3C8 provides a diagnostic and/or therapeutic target for prostate cancers.

L'invention concerne un nouveau gène (dénommé 3OP3C8) et sa protéine codée. 3OP3C8 présente une expression restreinte dans les tissus d'un adulte normal et est surexprimé dans les xénogreffes des tissus de la prostate, ce qui prouve qu'il est anormalement exprimé dans au moins quelques cancers de la prostate. Par conséquent, 3OP3C8 constitue une cible diagnostique et/ou thérapeutique pour les cancers de la prostate.

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