Prevention, treatment and amelioration of a pathology...

Details Prevention, treatment and amelioration of a pathology... Prevention, treatment and amelioration of a pathology...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 38/00 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2066738

An in vitro model of a blood-brain barrier comprising a porous solid support upon which is disposed an essentially confluent monolayer of brain microvascular endothelial cells in contact with agents that elevate effective cyclic AMP concentrations in endothelial cells, with or without astrocyte-derived or endothelial cell-derived conditioned medium or the equivalent so that high electrical resistance tight junctions are formed between endothelial cells, and endothelial cells exhibit peripheral phalloidin staining and E-cadherin. Also disclosed is the use of agents that reduce effective cyclic AMP concentrations or interfere with the functioning of cyclic AMP or increase effective cyclic GMP concentrations to open up blood-brain barriers in vitro and in vivo, so that drugs normally excluded by such barriers may substantially penetrate such barriers. Also disclosed are uses of the model to screen for reagents with clinical utility in disorders involving brain endothelial cells. The prevention, treatment, and amelioration of a pathology characterized by brain inflammation are described herein. Uses of agents that inhibit binding of VLA-4 to brain endothelial receptor VCAM-1 are included. These agents may be antibodies, peptides, peptidomimetics, or related compounds.

Affiliated with

Also associated with

Rating

Prevention, treatment and amelioration of a pathology... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Prevention, treatment and amelioration of a pathology..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Prevention, treatment and amelioration of a pathology... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1609813