C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) A61K 38/16 (2006.01) A61K 38/19 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C07K 14/52 (2006.01) C12N 15/12 (2006.01) C12N 15/19 (2006.01) C12N 15/63 (2006.01) C12N 15/64 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2310892
The present invention relates to a novel CK.alpha.-5 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CK.alpha.-5 protein. CK.alpha.-5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CK.alpha.-5 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
L'invention concerne une protéine CK.alpha.-5 membre de la famille des chémokines alpha, et en particulier des molécules d'acides nucléiques isolées qui codent la protéine humaine CK.alpha.-5. L'invention concerne également des polypeptides CK.alpha.-5, des vecteurs, des cellules hôtes et des procédés de recombinaison permettant d'élaborer les produits considérés. L'invention concerne en outre des procédés de criblage permettant d'identifier des agonistes et des antagonistes vis-à-vis de l'activité de CK.alpha.-5. L'invention concerne enfin des procédés diagnostiques permettant de détecter des troubles liés au système immunitaire, et des procédés thérapeutiques relatifs au traitement des troubles en question.
Li Yi
Ni Jian
Rosen Craig A.
Ruben Steven M.
Wei Ying-Fei
Human Genome Sciences Inc.
Mbm Intellectual Property Law Llp
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