Self-emulsifying compositions, methods of use and preparation

Details Self-emulsifying compositions, methods of use and preparation Self-emulsifying compositions, methods of use and preparation

A - Human Necessities

61

K

A61K 9/107 (2006.01)

Patent

CA 2519300

Preparation of self-emulsifying compositions which are prepared without mechanical homogenization is described. These self-emulsifying compositions are prepared using one or two surfactants. This provides the advantage of a low weight ratio of emulsifying component to oil component and fewer chemical toxicity concerns, resulting in comfort and safety advantages over emulsions employing more than two emulsifiers. Consequently, the self-mulsifying compositions described are ideally suited for ophthalmic applications including administration of therapeutics to the eye. Self-emulsifying compositions prepared by the disclosed method are described.

L'invention concerne la préparation de compositions auto-émulsifiantes lesquelles sont préparées sans homogénéisation mécanique. Ces compositions auto-émulsifiantes sont préparées à l'aide d'un ou de deux tensioactifs. Ceci présente l'avantage d'un faible rapport pondéral entre le constituant émulsifiant et le constituant huileux, et de présenter moins de problème de toxicité chimique, ce qui apporte des avantages de confort et de sécurité par rapport aux émulsions utilisant plus de deux émulsifiants. Par conséquent, les compositions auto-émulsifiantes décrites sont idéalement adaptées à des applications ophtalmiques notamment l'administration d'agents thérapeutiques à l'oeil. Les compositions auto-émulsifiantes préparées selon le procédé sont décrites.

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