Manufacture of active highly phosphorylated human lysosomal...

Details Manufacture of active highly phosphorylated human lysosomal... Manufacture of active highly phosphorylated human lysosomal...

C - Chemistry, Metallurgy

12

N

C12N 9/16 (2006.01) A61K 38/46 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2711590

This invention provides compositions of active highly phosphorylated lysosomal sulfatase enzymes, their pharmaceutical compositions, methods of producing and purifying such lysosomal sulfatase enzymes and compositions and their use in the diagnosis, prophylaxis, or treatment of diseases and conditions, including particularly lysosomal storage diseases that are caused by, or associated with, a deficiency in the lysosomal sulfatase enzyme.

L'invention concerne des compositions d'enzymes de sulfatase lysosomales hautement phosphorylées actives, leurs compositions pharmaceutiques, des procédés de production et de purification de telles enzymes de sulfatase lysosomales et des compositions et leur utilisation dans le diagnostic, la prophylaxie ou le traitement de maladies et affections, y compris en particulier des maladies de stockage lysosomales qui sont provoquées par, ou associées à, une déficience en l'enzyme de sulfatase lysosomale.

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