C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/52 (2006.01) A61K 35/12 (2006.01) A61K 38/19 (2006.01) A61K 47/42 (2006.01) C07K 19/00 (2006.01) C12N 15/19 (2006.01) C12N 15/62 (2006.01)
Patent
CA 2667280
The present invention is directed stromal cell derived factor-1 peptides that have been mutated to make them resistant to digestion by the proteases dipeptidyl peptidase IV (DPPIV) and matrix metalloproteinase-2 (MMP-2) but which maintain the ability of native SDF-I to attract T cells. The mutants may be attached to membranes formed by self-assembling peptides and then implanted at sites of tissue damage to help promote repair.
La présente invention concerne des peptides du facteur dérivé des cellules stromales de type 1, soumis à une mutation destinée à les rendre résistants à la digestion par les protéases dipeptidyl peptidase IV (DPPIV) et métalloprotéinase-2 (MMP-2), mais conservant la capacité du SDF-1 natif à attirer les lymphocytes T. Ces mutants peuvent être fixés à des membranes formées par des peptides d'auto-assemblage, puis implantés sur des sites de lésion tissulaire afin d'en favoriser la réparation.
Lee Richard
Segers Vincent
Gowling Lafleur Henderson Llp
The Brigham And Women's Hospital Inc.
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