Phthalimide derivative metabotropic glutamate r4 ligands

Details Phthalimide derivative metabotropic glutamate r4 ligands Phthalimide derivative metabotropic glutamate r4 ligands

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 51/00 (2006.01) C07D 401/14 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2737699

Disclosed are mGluR4 positive allosteric modulator ligands of general formula (I) and radiolabeled derivates, their use as therapeutic agents for the treatment of central nervous system disorders modulated by mGluR4 and as ligands for the labeling and diagnostic imaging of mGluR4 in mammals.

L'invention porte sur des ligands modulateurs allostériques positifs au mGluR4 de la formule générale (I) et sur des dérivés radiomarqués, sur leur utilisation en tant qu'agents thérapeutiques pour le traitement de troubles du système nerveux central modulés par mGluR4 et en tant que ligands pour le marquage et l'imagerie de diagnostic de mGluR4 chez les mammifères.

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