Human monoclonal antibodies for brain tumor diagnosis and...

Details Human monoclonal antibodies for brain tumor diagnosis and... Human monoclonal antibodies for brain tumor diagnosis and...

C - Chemistry, Metallurgy

12

P

167/139, 167/37,

C12P 21/08 (2006.01) A61K 39/44 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2035088

ABSTRACT The present invention relates to monoclonal antibodies directed against neuroectodermal tumors produced by human hybridoma cell lines. These hybridomas are produced by the fusion of peripheral blood lymphocytes, obtained from patients with different neuroectodermal tumors, and a myeloma-like cell line, TM-H2-SP2. Five hybridomas, designated as BT27/lA2, BT27/2A3, BT32/A6, BT34/A5, and BT54/B8, all produced monoclonal IgM in a range of 2.4 to 44 µg/ml, had a similar pattern of reactivity against a panel of human tumor cell lines, and did not react with normal human astrocytes. All five human monoclonal antibodies (HmAbs) recognized a subpopulation of tumor cells and preliminary antigen characterization indicated that these HmAbs are directed to cell surface glycolipids. Cell sorting experiments suggest that the identified subpopulation may share certain properties with tumor stem cell. These HmAbs possess certain properties of reactivity that suggest potential roles for them in the future diagnosis and clinical management of human malignant gliomas.

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