Farnesyl pyrophosphate analogs

Details Farnesyl pyrophosphate analogs Farnesyl pyrophosphate analogs

C - Chemistry, Metallurgy

07

F

C07F 9/38 (2006.01) A61K 31/19 (2006.01) A61K 31/66 (2006.01) C07C 43/30 (2006.01) C07C 45/29 (2006.01) C07C 47/21 (2006.01) C07C 59/42 (2006.01) C07C 233/05 (2006.01) C07C 235/74 (2006.01)

Patent

CA 2079080

105/MRD68 109/MRD71 18500 TITLE OF THE INVENTION FARNESYL PYROPHOSPHATE ANALOGS ABSTRACT OF THE DISCLOSURE The present invention is directed to farnesyl pyrophosphate analogs which inhibit farnecyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemothera- peutic compositions containing the compounds of this invention, and methods for inhibiting farnesyl- protein transferase and the farnesylation of the oncogene protein Ras.

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