Methods for the synthesis of cyclic peptides

Details Methods for the synthesis of cyclic peptides Methods for the synthesis of cyclic peptides

C - Chemistry, Metallurgy

07

K

C07K 1/04 (2006.01) C07K 5/06 (2006.01) C07K 7/06 (2006.01)

Patent

CA 2673229

Methods for the synthesis of cyclic peptides are provided, as well as novel dipeptide compounds. The methods include the solid phase synthesis of a dipeptide, which is the coupled to a second peptide in a solid phase reaction. The peptide is then cyclized following the coupling reaction. The methods and dipeptides are particularly useful for the synthesis of MC-4 receptor agonist peptides.

La présente invention a trait à des procédés de synthèse de peptides cycliques, ainsi qu'à des composés dipeptidiques inédits. Lesdits procédés comprennent la synthèse en phase solide d'un dipeptide, qui est ensuite couplé à un second peptide dans le cadre d'une réaction en phase solide. Suite à la réaction de couplage, le peptide est cyclisé. Ces procédés et ces dipeptides se révèlent particulièrement utiles pour la synthèse de peptides agonistes du récepteur MC4.

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