C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/56 (2006.01) A01N 63/00 (2006.01) A61K 38/47 (2006.01) A61P 31/04 (2006.01) A61P 31/10 (2006.01) C07H 21/04 (2006.01) C07K 19/00 (2006.01) C12N 1/00 (2006.01) C12N 1/14 (2006.01) C12N 1/20 (2006.01) C12N 1/21 (2006.01) C12N 9/24 (2006.01) C12N 9/28 (2006.01) C12N 15/63 (2006.01) C12Q 1/34 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2511103
Isolated nucleic acid sequences and amino acid sequences for soluble, .beta.-N- acetylglucosaminidase or active fragments or variants thereof which promote detachment of bacterial cells from a biofilm are provided. An isolated mutant bacteria which forms biofilm colonies which tightly adhere to surface but which are unable to release cells into the medium or spread over the surface is also provided. In additions, methods are described for modulating detachment of bacterial cells from biofilm by mutating soluble,.beta.-N- acetylglucosaminidase or altering its expression or activity are also provided. Also provided are compositions, methods and devices for preventing, inhibiting and treating bacterial infections.
L'invention concerne des séquences d'acides nucléiques isolées et des séquences d'acides aminés pour une .beta.-N-acétylglucosaminidase soluble ou des fragments actifs ou des variants associés qui permettent de favoriser le détachemennt de cellules bactériennes d'un biofilm. Cette invention a aussi trait à une bactérie mutante isolée qui forme des colonies de biofilm qui adhèrent étroitement en surface, mais qui ne peuvent pas libérer de cellules dans le milieu ou se répandre en surface. En outre, ladite invention a pour objet la modulation du détachement des cellules bactériennes à partir du biofilm par mutation de la .beta.-N-acétylglucosaminidase soluble ou par altération de son expression ou de son activité, ainsi que des compositions, des méthodes et des dispositifs qui permettent de prévenir, d'inhiber et de traiter des infections bactériennes.
Ridout & Maybee Llp
University Of Medicine And Dentistry Of New Jersey
LandOfFree
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