Process and intermediates for chiral epoxides

C - Chemistry – Metallurgy – 07 – D

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C07D 301/02 (2006.01) C07C 303/30 (2006.01) C07C 309/63 (2006.01) C07D 303/48 (2006.01) C07D 307/33 (2006.01) C07C 309/65 (2006.01) C07C 309/73 (2006.01)

Patent

CA 2041368

X-7851 Abstract Chiral epoxybutyrates are prepared in high yield from novel dihydro-3R-substituted sulfonyloxy-4R- hydroxy-2-(3H)furanones via based catalyzed alcoholysis. The product chiral epoxy butyrates are useful inter- mediates for the synthesis of 1-carba-1-dethia cephem antibiotics.

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