A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/127 (2006.01) A61K 31/711 (2006.01) A61K 48/00 (2006.01) C12N 15/88 (2006.01)
Patent
CA 2263705
Highly efficient cationic liposomes have been developed as an improved delivery system for biologically--active reagents. A novel structure, the sandwich liposome, is formed and comprises one or more biologically active agents internalized between two bilamellar liposomes. This structure protects the incoming agent and accounts for the high efficiency of in vivo delivery and for the broad tissue distribution of the sandwich liposome complexes. These novel liposomes are also highly efficient carriers of nucleic acids. By using extruded DOTAP:cholesterol liposomes to form complexes with DNA encoding specific proteins, expression has been improved dramatically. Highest expression was achieved in the lung, while increased expression was detected in several organs and tissues.
On a mis au point des liposomes cationiques hautement efficaces servant de système d'apport amélioré pour des réactifs biologiquement actifs. Une nouvelle structure, le liposome en sandwich, est formée et comprend un ou plusieurs agents biologiquement actifs internalisés entre deux liposomes bilamellés. Cette structure protège l'agent arrivant et est responsable de l'efficacité élevée de l'apport in vivo et de la répartition tissulaire large des complexes de liposomes en sandwich. Ces nouveaux liposomes sont également des transporteurs hautement efficaces d'acides nucléiques. En utilisant des liposomes DOTAP:cholestérol extrudés pour former des complexes avec des protéines spécifiques de codage d'ADN, on a obtenu une amélioration spectactulaire de l'expression. Une expression maximum a été obtenue dans les poumons, alors qu'une expression accrue a été détectée dans plusieurs organes et tissus.
Pavlakis George N.
Smyth-Templeton Nancy
Department Of Health And Human Services The Government Of The United States Of America As Represented By
Smart & Biggar
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