C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/12 (2006.01) A61K 31/18 (2006.01) A61K 31/36 (2006.01) A61K 31/38 (2006.01) A61K 31/395 (2006.01) A61K 31/41 (2006.01) A61K 31/70 (2006.01) C07C 311/29 (2006.01) C07C 311/41 (2006.01) C07C 317/28 (2006.01) C07D 235/30 (2006.01) C07D 235/32 (2006.01) C07D 277/82 (2006.01) C07D 307/79 (2006.01) C07D 317/62 (2006.01) C07D 319/18 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 491/056 (2006.01) C07D 493/04 (2006.01) C07H 5/10 (2006.01) C07H 15/04 (
Patent
CA 2236236
Selected sulfonylalkanoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
Des composés sélectionnés de sulfonylalcanoylamino hydroxyéthylamino sulfonamides sont efficaces comme inhibiteurs de protéases rétrovirales, en particulier la protéase du VIH. La présente invention concerne de tels inhibiteurs de protéases rétrovirales, et elle concerne plus particulièrement des composés sélectionnés, une composition et un procédé nouveaux servant à inhiber les protéases rétrovirales telles que la protéase du virus de l'immunodéficience humaine (VIH), à prévenir de manière prophylactique l'infection rétrovirale ou la dissémination d'un rétrovirus. L'invention concerne également le traitement d'une infection rétrovirale.
Decrescenzo Gary A.
Devadas Balekudru
Freskos John N.
Getman Daniel P.
Lu Hwang-Fun
G.d. Searle & Co.
G.d. Searle Llc
Sim & Mcburney
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