Triterpene compositions and methods for use thereof

C - Chemistry – Metallurgy – 07 – J

Patent

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C07J 63/00 (2006.01) C12N 5/071 (2010.01) A61K 9/72 (2006.01) A61K 31/702 (2006.01) A61K 31/704 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07H 15/256 (2006.01) C07J 53/00 (2006.01)

Patent

CA 2330916

The invention provides novel saponin mixtures and compounds which are isolated from the species Acacia victoriae and methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoid moieties are attached. The mixtures and compounds have properties related to the regulation of apoptosis and cytotoxicity of cells and exhibit potent anti-tumor effects against a variety of tumor cells.

La présente invention concerne des nouveaux mélanges de saponine isolées de l'espèce Acacia victoriae ainsi que leurs méthodes d'utilisation. Ces composés peuvent renfermer une fraction triterpène, telle qu'un acide acacique ou oléanolique, à laquelle sont reliés des oligosaccharides et des fractions monoterpenoïdes. Ces mélanges et composés possèdent des propriétés en rapport avec la régulation de l'apoptose et la cytotoxicité et ont de puissants effets anti-tumoraux contre diverses cellules tumorales.

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