C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 1/22 (2006.01) C07K 1/16 (2006.01) C07K 1/20 (2006.01) C07K 1/32 (2006.01) G01N 30/02 (2006.01) G01N 30/06 (2006.01) G01N 30/88 (2006.01)
Patent
CA 2315887
The present invention is directed to novel methods for enhancing the ability to separate a species of interest from other different species present in a free solution mixture thereof which takes advantage of interactions that occur between soluble, small molecular weight ligands and the species of interest. The small molecular weight ligands employed in the present invention function to interact with a species of interest in a mixture of different species through either affinity, hydrophobic and/or ionic interactions, thereby altering the molecular weight, hydrodynamic volume and/or isoelectric point of the species of interest and rendering it separable from other component(s) in the mixture.
La présente invention concerne des procédés qui accroissent les possibilités de séparation de composés recherchés d'autres composés présents dans un mélange de ceux-ci en solution libre en tirant parti des interactions qui se produisent entre des ligands solubles de faible poids moléculaire et les composés recherchés. Dans une solution de composés différents, les ligands de faible poids moléculaire de la présente invention réagissent avec un composé recherché par interaction d'affinité, hydrophobe et/ou ionique, provoquant ainsi un changement du poids moléculaire, du volume hydrodynamique et/ou du point isoélectrique du composé recherché, lui conférant la possibilité d'être séparé des autres composants de la solution.
Dennison Associates
Genentech Inc.
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