A - Human Necessities – 61 – M
Patent
A - Human Necessities
61
M
A61M 1/00 (2006.01) A61K 38/17 (2006.01) A61M 5/142 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2543779
Methods and devices to attenuate tumor necrosis factor (TNF) and other pro- inflammatory mediators in the CNS to treat neurological, neurodegenerative, neuropsychiatric disorders, pain and brain injury are described. More particularly, TNF blocking agents that target intracellular signals and downstream effects associated with the production and secretion of TNF are described. Devices described include therapy delivery devices comprising a reservoir capable of housing a TNF blocking agent and a catheter operably coupled to the device and adapted to deliver the TNF blocking agent to a target site within a subject.
L'invention se rapporte à des procédés et à des dispositifs permettant d'atténuer le facteur de nécrose tumorale (TNF) et d'autres médiateurs pro-inflammatoires dans le Système Nerveux Central de façon à traiter des troubles neurologiques, neurodégénérateurs et neuropsychiatriques, ainsi que la douleur et des lésions cérébrales. Plus particulièrement, l'invention se rapporte à des agents bloquant le TNF qui ciblent les signaux intracellulaires et les effets aval associés à la production et à la sécrétion du TNF. Les dispositifs décrits comprennent des dispositifs d'administration thérapeutiques comportant un réservoir pouvant renfermer un agent bloquant le TNF et un cathéter couplé fonctionnellement au dispositif et conçu pour délivrer l'agent bloquant le TNF à un site cible chez un sujet.
Mckay William F.
Shafer Lisa L.
Medtronic Inc.
Smart & Biggar
Warsaw Orthopedic Inc.
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