A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/726 (2006.01)
Patent
CA 2617484
This invention provides for the use of compounds represented by the structure of the general formula (A): wherein L is a lipid or a phospholipid, Z is either nothing, ethanolamine, serine, inositol, choline, or glycerol, Y is either nothing or a spacer group ranging in length from 2 to 30 atoms, X is a physiologically acceptable monomer, dimer, oligomer, or polymer, wherein X is a glycosaminoglycan; and n is a number from 1 to 1000, wherein any bond between L, Z, Y and X is either an amide or an esteric bond in treating a subject suffering from cystic fibrosis, reducing or delaying the mortality of a subject suffering from cystic fibrosis or ameliorating symptoms associated with cystic fibrosis.
La présente invention concerne l'utilisation de composés représentés par la structure de la formule générale (A) pour traiter un sujet souffrant de fibrose cystique, réduire ou ralentir la mortalité d'un sujet souffrant de fibrose cystique, ou améliorer les symptômes liés à la fibrose cystique. Dans cette formule, L est lipide ou phospholipide. Z est néant, éthanolamine, sérine, inositol, choline, ou glycérol. Y est néant ou groupe intercalaire de 2 à 30 atomes de long. X est monomère, dimère, oligomère, ou polymère physiologiquement admis. En outre, X est un glycosaminoglycan, et n est un nombre valant de 1 à 1000. Enfin, toutes les liaisons entre L, Z, Y et X sont soit un amide soit une liaison estérique.
Prince Alice
Yedgar Saul
Yuval Cohen
Morria Biopharmaceuticals
Riches Mckenzie & Herbert Llp
The Trustees Of Columbia University
Yissum Research Development Company Of The Hebrew University Of
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