A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/28 (2006.01) A61K 9/00 (2006.01) A61K 9/16 (2006.01) A61K 31/485 (2006.01) A61K 38/23 (2006.01) A61K 47/36 (2006.01) A61K 47/38 (2006.01)
Patent
CA 2197062
A drug delivery composition for administration to mucosa is provided. The composition comprises a pharmacologically active compound and particles, preferably powder or microspheres, of chitosan or a chitosan derivative or salt wherein the particles are either solidified or partially cross-linked such that they have a zeta-potential of +0.5 to +50 mV. Solidified particles are made by treating particles made from a water soluble chitosan salt with an alkaline agent such as sodium hydroxide in non-acid containing water to render them insoluble.
On décrit une composition d'apport de médicaments destinée à être administrée aux muqueuses. Elle comprend un composé pharmacologiquement actif et des particules, de la poudre ou des microsphères de préférence, de chitosane ou d'un de sels ou dérivés, particules qui sont solidifiées ou partiellement réticulées de façon à présenter un potentiel zêta allant de +0,5 à +50 mV. On obtient des particules solidifiées en traitant des particules d'un sel de chitosane hydrosoluble avec un agent alcalin tel que l'hydroxyde de sodium dans une eau ne contenant aucun acide, ce qui les rend insolubles.
Illum Lisbeth
Watts Peter James
Archimedes Development Limited
Borden Ladner Gervais Llp
Danbiosyst Uk Limited
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