Method of increasing bone toughness and stiffness and...

A - Human Necessities – 61 – K

Patent

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A61K 38/29 (2006.01)

Patent

CA 2325371

The invention relates to a method for increasing the toughness and/or stiffness of bone and/or reducing the likelihood and/or severity of bone fracture by administering a parathyroid hormone. The method can be employed to increase toughness or stiffness of bone at a site of a potential or actual trauma, such as the hip or spine of a person at risk of or suffering from osteoporosis. The method of the invention can reduce the incidence of vertebral fracure, reduce the incidence of multiple vertebral fractures, reduce the severity of vertebral fracture, and/or reduce the incidence of non-vertebral fracture.

L'invention concerne un procédé qui permet d'augmenter la solidité et/ou la rigidité osseuse et/ou de réduire le risque et/ou la gravité des fractures, en administrant une hormone parathyroïde. On peut utiliser ce procédé pour augmenter la solidité ou la rigidité osseuse sur un site de traumatisme potentiel ou réel, par exemple sur la hanche ou sur la colonne vertébrale d'une personne risquant de souffrir d'ostéoporose ou souffrant d'ostéoporose. Le procédé considéré permet de réduire l'incidence d'une ou plusieurs fractures vertébrales, et de réduire la gravité de ce type de fracture, et/ou de réduire l'incidence des fractures non vertébrales.

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