C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 17/08 (2006.01) A61K 31/70 (2006.01)
Patent
CA 2370273
The invention relates to novel 15-membered 8a- and 9a-lactams from the class of 6-O-methyl-erythromycin A of general formula (I), their pharmaceutically acceptable addition salts with inorganic or organic acids and their hydrates, wherein A stands for NH group and B simultaneously stands for C=O group, or A stands for C=O group and B simultaneously stands for NH group, and the radicals R1, R2, R3, R4, R5, R6 have the meaning given in claim 1.
La présente invention concerne de nouveaux lactames 8a et 9a à 15 éléments issus de la classe du composé 6-O-méthyl-érythromycine A de formule (I), leurs sels d'addition pharmaceutiquement acceptables avec des acides organiques ou inorganiques et leurs hydrates. Dans la formule (I), A représente un groupe NH et B représente simultanément un groupe C=O, ou A représente un groupe C=O et B représente simultanément un groupe NH ; les radicaux R?1¿, R?2¿, R?3¿, R?4¿, R?5¿ et R?6¿ correspondent à la signification donnée dans la revendication 1.
Alihodzic Sulejman
Kobrehel Gabrijela
Lazarevski Gorjana
Mutak Stjepan
Borden Ladner Gervais Llp
Dionicko Drustvo Pliva Farmaceutska Industrija
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