Modulation of stem and progenitor cell differentiation,...

A - Human Necessities – 61 – K

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A61K 35/14 (2006.01) C12N 5/0789 (2010.01) A61K 31/454 (2006.01) A61K 35/12 (2006.01) C12N 5/02 (2006.01)

Patent

CA 2481386

The present invention relates to methods of modulating mammalian stem cell and progenitor cell differentiation. The methods of the invention can be employed to regulate and control the differentiation and maturation of mammalian, particularly human stem cells along specific cell and tissue lineages. The methods of the invention relate to the use of certain small organic molecules to modulate the differentiation of stem or progenitor cell populations along specific cell and tissue lineages, and in particular, to the differentiation of embryonic-like stem cells originating from a postpartum placenta or for the differentiation of early progenitor cells to a granulocytic lineage. Finally, the invention relates to the use of such differentiated stem or progenitor cells in transplantation and other medical treatments.

La présente invention se rapporte à des procédés de modulation de la différenciation de cellules souches et de cellules progénitrices de mammifère. Ces procédés peuvent être mis en oeuvre pour réguler et surveiller la différenciation et la maturation de cellules souches mammaliennes, en particulier humaines, ainsi que de lignées cellulaires et tissulaires spécifiques. Les procédés de la présente invention font appel à certaines petites molécules organiques pour moduler la différenciation de populations de cellules souches ou progénitrices ainsi que de lignées cellulaires et tissulaires spécifiques, et en particulier la différenciation de cellules souches de type embryonnaire provenant d'un placenta de post-partum ou la différenciation de cellules progénitrices précoces en une lignée granulocytique. L'invention se rapporte finalement à l'utilisation de telles cellules souches ou progénitrices différenciées à des fins de transplantation et d'autres traitements médicaux.

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