Nitrooxyderivatives of antihypertensive drugs

Details Nitrooxyderivatives of antihypertensive drugs Nitrooxyderivatives of antihypertensive drugs

C - Chemistry, Metallurgy

07

D

C07D 285/10 (2006.01) A61K 31/433 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2548127

The present invention relates to .beta.-adrenergic blockers nitrooxyderivatives of general formula (I): A-(Y-ONO2)s and enantiomers and diastereoisomers and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them and their use for the treatment of hypertension, cardiovascular diseases, glaucoma, migraine headache and vascular diseases.

L'invention concerne des nitro-oxydérivés bêta-bloquants de formule générale (I) A-(Y-ONO¿2?)¿s?, y compris les énantiomères, diastéréoisomères et sels pharmaceutiquement acceptables correspondants, des compositions pharmaceutiques les renfermant, et leur utilisation pour le traitement de l'hypertension, des maladies cardio-vasculaires, du glaucome, de la migraine et des maladies vasculaires.

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