Immunoglobulin cleavage fragments as disease indicators and...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/42 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) A61P 19/02 (2006.01) C07K 14/435 (2006.01) C07K 16/00 (2006.01) C12Q 1/37 (2006.01) G01N 33/564 (2006.01)

Patent

CA 2696011

The invention relates to antibody compositions and use of the composition to detect disease processes associated with elaboration of proteases. The reagents are directed to assessing an IgG breakdown product that is the result of such proteolytic cleavage. The invention further relates to the use of a therapeutic immunospecific for IgG breakdown products retaining antigen binding but having lost effector functions.

Cette invention a trait à des compositions d'anticorps et à l'utilisation de ces compositions pour détecter des processus pathologiques associés avec l'élaboration de protéases. Les réactifs sont orientés de manière à évaluer le produit de décomposition des IgG qui est le résultat de ce clivage protéolytique. L'invention concerne par ailleurs l'utilisation d'un composé thérapeutique immunospécifique des produits de décomposition des IgG conservant la fonction de fixation antigénique mais dépourvu des fonctions effectrices.

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