Preparation of n-protected-3-pyrrolidine-lactam substituted...

C - Chemistry – Metallurgy – 07 – F

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C07F 9/6558 (2006.01) C07D 207/14 (2006.01) C07D 207/26 (2006.01) C07D 207/273 (2006.01) C07D 207/416 (2006.01) C07D 501/00 (2006.01) C07F 9/572 (2006.01)

Patent

CA 2418970

New process for the preparation of bipyrrolidinyl compounds of formula I wherein * signifies an asymmetric centre with an (R) or (S) configuration and X represents chlorine, bromine or iodine. The compounds of formula I are important building blocks for the production of useful products in the chemical and in the pharmaceutical industry. In particular they are useful for the production of antibacterial substances for example like vinylpyrrolidinone- cephalosporin derivatives.

L'invention concerne un nouveau procédé de préparation de composés bipyrrolidinyle de formule (I) dans laquelle * représente un centre asymétrique à configuration (R) ou (S) et X représente chlore, brome ou iode. Les composés de formule (I) sont des blocs de construction importants pour la production de produits utiles dans l'industrie chimique et pharmaceutique. Les composés sont notamment utiles dans la production de substances antibactériennes, telles que des dérivés de vinylpyrrolidinone-céphalosporine.

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