Methods of using mammalian rnase h and compositions thereof

Details Methods of using mammalian rnase h and compositions thereof Methods of using mammalian rnase h and compositions thereof

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) A61K 31/7088 (2006.01) A61K 38/46 (2006.01) A61K 39/395 (2006.01) C07H 21/04 (2006.01) C12N 9/22 (2006.01) C12N 15/11 (2006.01) C12Q 1/34 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2437887

The present invention relates to methods for using mammalian RNase H, including human RNase H, and compositions thereof, particularly for reduction of a selected cellular RNA target via antisense technology. A novel human RNAse HII polypeptide and the polynucleotide sequence encoding it are also disclosed.

L'invention concerne des procédés d'utilisation de la RNase H de mammifère, y compris de la RNase H humaine et des compositions de celle-ci, en particulier pour la réduction d'une cible ARN cellulaire sélectionnée par le biais de la technologie antisens. L'invention concerne également un nouveau polypeptide de RNase HII et la séquence de polynucléotides codant ce polypeptide.

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