A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/047 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2683546
The present invention relates to methods for treating .alpha.-synucleinopathies, methods for modulating of assembly, folding, accumulation, oligomerization, rate of aggregation, oligomerization and clearance of proteins of fragments comprising .alpha.-synuclein aggregates in a subject, by administering a medicament comprising a therapeutically effective amount of a cyclohexanehexol derivative. More specifically, the invention provides medicaments comprising at least one cyclohexanehexol derivative of formula (III) or (IV) useful in improving neuron, glia and oligodendrocyte function, for slowing the degeneration and death of neurons, glial cells and oligodendrocytes in the brain and treating synucleinopathies such as Parkinson's disease. These medicaments are formulated for oral and parenteral administration. Formulae (III), (IV).
La présente invention concerne des méthodes permettant de traiter des .alpha.-synucléinopathies, des méthodes permettant de moduler l'assemblage, le pliage, l'accumulation, l'oligomérisation, le taux d'agrégation, l'oligomérisation et la clairance de protéines de fragments comprenant des agrégats d'.alpha.-synucléine chez un sujet, par administration d'un médicament contenant une quantité efficace thérapeutiquement d'un dérivé de cyclohexanehexol. Plus spécifiquement, l'invention concerne des médicaments contenant au moins un dérivé de cyclohexanehexol de formule (III) ou (IV) utilisé pour améliorer la fonction des neurones, des cellules gliales et des oligodendrocytes, afin de ralentir la dégénération et la mort des neurones, des cellules gliales et des oligodendrocytes dans le cerveau et de traiter des synucléinopathies, telles que la maladie de Parkinson. Ces médicaments sont préparés en vue d'une administration orale et parentérale. Formules (III), (IV).
Mclaurin Joanne
Mccarthy Tetrault Llp
Mclaurin Joanne
LandOfFree
Use of cyclohexanehexol derivatives in the treatment of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of cyclohexanehexol derivatives in the treatment of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of cyclohexanehexol derivatives in the treatment of... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1623651