C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/05 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2341351
The present invention relates to three novel genes and polypeptides derived therefrom encoding ".alpha.2.delta.-C" and/or ".alpha.2.delta.-D" proteins which exist as a subunit in many calcium channels. The invention also describes methods for using the novel gene and polypeptides in the detection of genetic deletions of the gene, subcellular localization of the polypeptide, binding assays in connection with chemical databases, gene therapy.
La présente invention concerne trois nouveaux gènes ainsi que des polypeptides dérivés de ces derniers codant pour les protéines ".alpha.2.delta.-C" et/ou ".alpha.2.delta.-D" présentes, en tant que sous-unités, dans un grand nombre de canaux calciques. L'invention porte également sur des procédés d'utilisation des nouveaux gènes et polypeptides, en vue de la détection de délétions génétiques, la localisation subcellulaire des polypeptides, la réalisation d'analyses de liaisons dans le cadre de bases de données chimiques, l'application de thérapies géniques.
Johns Margaret Ann
Moldover Brian
Offord James David
Macrae & Co.
Warner-Lambert Company
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