A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/02 (2006.01) A61K 31/00 (2006.01)
Patent
CA 2442457
Methods and compositions are provided for treating vascular disease and modulating the inflammatory and immune processes using carbon monoxide generating compounds, including methylene chloride. The subject compounds are capable of inhibiting the proliferation of vascular smooth muscle cells, protecting the vasculature against oxidative stress and injury, modulating the activity of various immune system cells, inhibiting the production of pro- inflammatory cytokines and enhancing production of anti-inflammatory cytokines, thereby being effective in the treatment of conditions associated with adverse proliferative or inflammatory responses. Methods for extending the survival of an organ transplant and inhibiting chronic rejection in a recipient are also provided.
L'invention concerne des méthodes et des compositions permettant de traiter les maladies vasculaires et de modifier les processus inflammatoires et immunitaires au moyen de composés générateurs de monoxyde de carbone, comprenant notamment le chlorure de méthylène. Ces composés sont capable d'inhiber la prolifération des cellules des muscles lisses vasculaires et de protéger le systèmes vasculaire contre le stress oxydatif et les lésions, de moduler l'activité de diverses cellules du système immunitaire, d'inhiber la production de cytokines pro-inflammatoires et de stimuler la production de cytokines anti-inflammatoires, et sont ainsi efficaces pour le traitement des pathologies liées à une réponse proliférative ou inflammatoire indésirable. L'invention concerne en outre des procédés permettant d'allonger la survie d'un organe transplanté et d'inhiber le rejet chronique chez le receveur.
Buelow Roland
Woo Jacky
Sangstat Medical Corporation
Smart & Biggar
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