A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/59 (2006.01) A61K 31/592 (2006.01) A61K 31/593 (2006.01) A61P 3/02 (2006.01) A61P 3/14 (2006.01)
Patent
CA 2224284
The 19-nor-vitamin D analogs, and particularly 19-nor-1.alpha.,25- dihydroxyvitamin D2, possess low calcemic and phosphatemic activity while also having the ability to suppress parathyroid hormone (PTH) production. The suppressive effect on PTH secretion of these 19- nor analogs without significant changes in serum calcium or serum phosphorus make them ideal tools for the treatment of secondary hyperparathyroidism in patients having kidney disorders.
Les analogues de la 19-nor-vitamine D, et particulièrement la 19-nor-1 alpha ,25-dihydroxyvitamine D2, possèdent une faible activité calcémique et phosphatémique tout en ayant la capacité de supprimer la production d'hormone parathyroïde (PTH). L'effet suppressif sur la sécrétion de PTH de ces analogues 19-nor sans modification significative dans le calcium sérique ou dans le phosphore sérique en fait des outils idéaux pour le traitement de l'hyperparathyroïdisme secondaire chez les patients souffrant de troubles rénaux.
Deluca Hector F.
Slatopolsky Eduardo
Borden Ladner Gervais Llp
Washington University
Wisconsin Alumni Research Foundation
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