G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/558 (2006.01) C12Q 1/68 (2006.01) G01N 33/543 (2006.01)
Patent
CA 2246987
A chromatographic strip positive readout binding assay device and method suitable for quick, sensitive and reliable field testing for small molecules such as environmental contaminants, drugs of abuse, therapeutic drugs and hormones. The detectable label is not attached to either the analyte or to the analyte receptor. Low affinity binding pairs can be used in the positive readout binding assay. The strip comprises a sample contact zone, a trapping zone and a detection zone arranged along the strip in the direction of sample flow. The trapping zone comprises a binding partner in sufficient amount to bind enough of a first unlabelled binding partner so that substantially all of a labelled anti-first binding partner bound to the first binding partner is captured in the trapping zone.
La présente invention concerne un testeur par liaisons affichant positivement les résultats de mesure des raies chromatographiques. Ce testeur convient particulièrement à la recherche sur site de petites molécules telles que celles des polluants, des substances toxiques entraînant une pharmacodépendance, des médicaments thérapeutiques et des hormones. L'étiquette détectable ne se fixe, ni sur le produit recherché, ni sur le récepteur du produit recherché. Pour un tel test par liaisons à affichage positif des résultats de mesure, on peut utiliser des paires de liaison à faible affinité.
Ensys Environmental Products Inc.
Finlayson & Singlehurst
LandOfFree
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