Inhibitors of integrin .alpha.v.beta.3

Details Inhibitors of integrin .alpha.v.beta.3 Inhibitors of integrin .alpha.v.beta.3

C - Chemistry, Metallurgy

07

D

C07D 213/74 (2006.01) A61K 31/4168 (2006.01) A61K 31/4184 (2006.01) A61K 31/44 (2006.01) A61K 31/4402 (2006.01) A61K 31/505 (2006.01) A61P 9/10 (2006.01) A61P 35/00 (2006.01) C07D 233/88 (2006.01) C07D 235/30 (2006.01) C07D 239/42 (2006.01) C07D 333/48 (2006.01) C07D 409/12 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2382561

The invention relates to novel compounds of formula (I) which are biologically active as .alpha.v.beta.3 integrin ligands X-Y-Z-R1-CH2-R2(R4)-CH2-CO-R5, whereby X, Y, Z, R1, R2, R4 and R5 have meanings cited in Claim (1). The invention also relates to the physiologically acceptable salts and solvates thereof.

L'invention concerne de nouveaux composés de formule (I), qui sont biologiquement efficaces en tant que ligands de l'intégrine .alpha.¿v?.beta.¿3?, formule X-Y-Z-R?1¿-CH¿2?-R?2¿(R?4¿)-CH¿2?-CO-R?5¿ dans laquelle X, Y, Z, R?1¿, R?2¿, R?4¿ et R?5¿ ont les significations données dans la revendication 1, ainsi que les sels et solvates physiologiquement acceptables de ces composés.

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