Alkenyldiarylmethanes, fused analogs and syntheses thereof

Details Alkenyldiarylmethanes, fused analogs and syntheses thereof Alkenyldiarylmethanes, fused analogs and syntheses thereof

C - Chemistry, Metallurgy

07

C

C07C 69/76 (2006.01) A61K 31/216 (2006.01) A61K 31/277 (2006.01) A61K 31/42 (2006.01) A61P 31/18 (2006.01) C07C 255/57 (2006.01) C07D 261/20 (2006.01) C07D 263/22 (2006.01)

Patent

CA 2613962

Non-nucleoside inhibitors of HIV-I reverse transcriptase are described. Such inhibitors may be used as part of a combination therapy to treat HIV infection. Compounds described herein exhibit antiviral potency. In addition, compounds described herein exhibit metabolic stability. Also described herein are processes for preparing Non-nucleoside inhibitors of HIV-I reverse transcriptase.

L'invention concerne des inhibiteurs non nucléosidiques de la transcriptase inverse du VIH-I. Ces inhibiteurs peuvent être partiellement impliqués dans une polythérapie visant à traiter l'infection à VIH. Les composés de l'invention possèdent en outre un effet antiviral puissant, et se caractérisent par une stabilité métabolique. Par ailleurs, l'invention concerne des procédés de préparation de ces inhibiteurs non nucléosidiques de la transcriptase inverse du VIH-I.

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