C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/713 (2006.01) A61K 35/76 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61P 3/10 (2006.01) A61P 19/02 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) A61P 37/02 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/08 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01)
Patent
CA 2406132
A novel polypeptide ligand, p30, or LIGHT, for herpes virus entry mediator, HVEM, is provided. p30 is useful for modulating immune responses and in inhibiting infection and/or subsequent proliferation by herpes virus. HVEM fusion proteins are also provided. Methods for treating subjects with lymphoid cell disorders, tumors, autoimmune diseases, inflammatory disorders of those having or suspected of having a herpes virus infection, utilizing p30 and the fusion proteins of the invention, are also provided.
La présente invention concerne un nouveau ligand polypeptidique, la p30, ou LIGHT, pour le médiateur d'entrée du virus herpès simplex (HVEM). La p30 est utilisable pour modifier les réponses immunitaires et inhiber l'infection et/ou la prolifération ultérieure par le virus herpès. L'invention concerne également des protéines hybrides HVEM. L'invention concerne en outre des procédés de traitement de sujets souffrant de troubles de cellules lymphoïdes, de tumeurs, de maladies auto-immunes, de troubles inflammatoires de ceux souffrant ou susceptibles de souffrir d'une infection du virus herpès, mettant en oeuvre la p30 et les protéines hybrides de l'invention.
La Jolla Institute For Allergy And Immunology
Mbm Intellectual Property Law Llp
LandOfFree
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