Microcapsules having delayed release

Details Microcapsules having delayed release Microcapsules having delayed release

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 8/11 (2006.01) A61K 8/73 (2006.01) A61Q 13/00 (2006.01) B01J 13/10 (2006.01)

Patent

CA 2325554

The inventive method for producing microcapsules is characterised in that a) in one step, liquid drops of an aqueous solution (1) containing at least one water-soluble polyanion are added to an aqueous solution (2) containing the following: 0.1 to 5 wt. % calcium cations; and 0.1 to 5 wt. % hydrolyzed chitosan with a number average molecular weight of between 2,200 and 40,000 g/mol., obtained by partial hydrolysis of a chitosan with a number average molecular weight of more than 50,000 g/mol. in an aqueous solution containing 0.1 to 4 N HCl at a temperature of between 50 and 95 ~C for 0.5 to 8 hours, the weight ratio of the solution containing HCl to usual commercial chitosan being between 1 and 50 and the product of normality of the HCl solution and the duration of hydrolysis in hours being between 0.1 and 7; and in that b) once the addition of solution 1 is complete, the resulting microcapsules remain in solution 2 for a duration of 15 to 360 minutes, preferably 60 to 180 minutes.

L'invention concerne un procédé de production de microcapsules. Ce procédé consiste a) à ajouter, en une opération, des gouttelettes d'une solution aqueuse (1) contenant au moins un polyanion soluble dans l'eau, dans une solution aqueuse (2) qui contient 0,1 à 5 % en poids de cations de calcium; et 0,1 à 5 % en poids de chitosane hydrolysé ayant un poids moléculaire moyen compris entre 2.200 et 40.000 g/mol, cette substance pouvant être obtenue par hydrolyse partielle d'un chitosane ayant un poids moléculaire moyen de plus de 50.000 g/mol dans une solution aqueuse contenant 0,1 à 4 N HCl à une température comprise entre 50 et 95 ·C pendant un temps compris entre 0,5 et 8 heures, le rapport du poids de la solution contenant le HCl par rapport au poids de chitosane courant dans le commerce est compris entre 1 et 50 et le produit de normalité de la solution HCl et la durée d'hydrolyse est compris entre 0,1 et 7 heure. Une fois la solution (1) ajoutée, ce procédé consiste b) à laisser les microcapsules ainsi obtenues dans la solution (2) pendant 15 à 360 minutes, notamment pendant 60 à 180 minutes.

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