Secreted proteins and nucleic acids encoding them

Details Secreted proteins and nucleic acids encoding them Secreted proteins and nucleic acids encoding them

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) C07H 19/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 1/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 17/00 (2006.01) C12N 1/00 (2006.01) C12N 5/02 (2006.01) C12N 15/09 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) C12N 15/70 (2006.01) C12N 15/74 (2006.01) C12N 15/85 (2006.01) C12N 15/87 (2006.01) C12P 21/00 (2006.01) C12P 21/06 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (

Patent

CA 2362924

The invention provides isolated nucleic acid molecules, designated TANGO 216, TANGO 261, TANGO 262, TANGO 266, and TANGO 267. These nucleic acid molecules encode wholly secreted and transmembrane proteins. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

La présente invention concerne des molécules d'acides nucléiques isolés, portant les désignations TANGO 216, TANGO 261, TANGO 262, TANGO 266, et TANGO 267. Ces molécules d'acides nucléiques codent pour des protéines totalement sécrétées et transmembranaires. L'invention concerne également des molécules d'acides nucléiques antisens, des vecteurs d'expression contenant les molécules d'acides nucléiques de l'invention, des cellules hôtes dans lesquelles ont été introduits les vecteurs d'expression, et des animaux transgéniques non humains dans lesquels a été introduite ou interrompue une molécule d'acide nucléique de l'invention. L'invention concerne en outre des polypeptides isolés, des polypeptides de fusion, des peptides antigènes et anticorps. L'invention concerne enfin des techniques de diagnostic, de recherche systématique et de traitement mettant en oeuvre les compositions de l'invention.

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