Optically active azole derivatives, their production and use

Details Optically active azole derivatives, their production and use Optically active azole derivatives, their production and use

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 487/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2134417

A process for preparing a compound of the formula (IV) or a salt thereof, Image [IV] , wherein R1 is an optionally substituted aliphatic or aromatic hydrocarbon residue or an optionally substituted aromatic heterocyclic group, one of Y and Z is a nitrogen atom and the other is a methine group which may be optionally substituted with a lower alkyl group, Ar is a halogenated phenyl group, and (R) shows that the carbon atom marked with (R) has (R)-configuration, in a short period, by simple processes and with high yield and purity; and an azole compound of the formula (IV'), Image [IV'] , wherein Ar' is a monofluorophenyl group, and the other symbols have the same meanings as above, or a salt thereof, which are useful for an antifungal therapeutic agent.

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