Formulations useful for modulating expression of exogenous...

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) A61K 31/33 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2328521

In accordance with the present invention, there are provided various methods for modulating the expression of an exogenous gene in a mammalian subject employing modified ecdysone receptors. Also provided are modified ecdysone receptors, as well as homomeric and heterodimeric receptors containing same, nucleic acids encoding invention modified ecdysone receptors, modified hormone response elements, gene transfer vectors, recombinant cells, and transgenic animals containing nucleic acids encoding invention modified ecdysone receptor.

L'invention porte sur divers procédés de modulation de l'expression d'un gène endogène chez un sujet mammalien au moyen de récepteurs d'ecdysone modifiés. L'invention porte également sur des récepteurs d'ecdysone modifiés ainsi que sur des récepteurs homomères et hétérodimères les contenant, sur des acides nucléiques codant les récepteurs d'ecdysone modifiés de l'invention, sur des éléments modifiés de réaction hormonale, sur des vecteurs de transfert de gènes, sur des cellules de recombinaison et sur des animaux transgéniques possédant des acides nucléiques codant le récepteur d'ecdysone modifié de l'invention.

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