Hexahydroaphthalene ester derivatives, their preparation and...

Details Hexahydroaphthalene ester derivatives, their preparation and... Hexahydroaphthalene ester derivatives, their preparation and...

C - Chemistry, Metallurgy

12

P

C12P 17/06 (2006.01) A61K 31/215 (2006.01) A61K 31/365 (2006.01) C07C 69/30 (2006.01) C07C 69/52 (2006.01) C07C 69/675 (2006.01) C07C 309/63 (2006.01) C07D 309/30 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07F 7/18 (2006.01) C12N 9/02 (2006.01) C12P 7/62 (2006.01)

Patent

CA 2112442

ABSTRACT OF THE DISCLOSURE Compounds of formula (I): Image (I) [wherein R1 represents a group of formula (II) or (III): Image (II) (III) R2 is alkyl, alkenyl or alkynyl; R3 and R4 are each hydrogen, alkyl, alkenyl or alkynyl; R5 is hydrogen or a carboxy-protecting group; Ra is hydrogen or a group of formula and -OR6; R6, R6a and R6b are each hydrogen, a hydroxy-protecting group, alkyl, alkanesulfonyl, halogenated alkanesulfonyl or arylsulfonyl] and their salts and esters have the ability to inhibit the synthesis of cholesterol, and can thus be used for the treatment and prophylaxis of hypercholesterolemia and of various cardiac disorders.

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