Processes for preparing triethanolamine salts of low...

Details Processes for preparing triethanolamine salts of low... Processes for preparing triethanolamine salts of low...

A - Human Necessities

61

K

A61K 31/727 (2006.01) A61K 31/133 (2006.01) A61P 7/02 (2006.01) C08B 37/00 (2006.01)

Patent

CA 2491398

Low molecular weight heparin salt with triethanolamine useful as a therapeutic-antithrombotic agent for local delivery, having at least 60% of its total mass a molecular weight of less than 8000 Da and an average molecular weight from 4000 to 6000 Da, said salt also having a content of organic sulfur from 6.1 to 7,5 weight % (theoretical 6.8%) and a triethanolamine content from 42,6 to 52,1 weight % (theoretical 47,4 weight %). The processes for preparing the heparin salt, eliminating hygroscopicity of said salt, and pharmaceutical compositions for use in local antithrombotic therapy and its uses are also disclosed.

Sel d'héparine de basse masse moléculaire avec du 2,2',2''-nitrilotriséthanol utile comme agent thérapeutique/antithrombotique pour application locale, dont au moins 60 % de sa masse totale a une masse moléculaire inférieure à 8000 Da et dont la masse moléculaire moyenne va de 4000 à 6000 Da. Ledit sel a aussi une teneur en soufre organique de 6,1 à 7,5 % en poids (théoriquement de 6,8 %) et une teneur en 2,2',2''-nitrilotriséthanol de 42,6 to 52,1 % en poids (théoriquement de 47,4 %). On divulgue aussi le procédé pour préparer ce sel d'héparine et éliminer l'hygroscopicité dudit sel, ainsi que des compositions pharmaceutiques pour usage en thérapie antithrombotique locale et leurs utilisations.

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