C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/19 (2006.01) C07K 14/435 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C12N 1/21 (2006.01) C12N 15/64 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2295326
The present invention relates to a novel CLC protein which is a member of the IL-6 cytokine family. In particular, isolated nucleic acid molecules are provided encoding the human CLC protein. CLC polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagoniest of CLC activity. Also provided are diagnostic methods for detecting cardiac and immune system-related disorders and therapeutic methods for treating cardiac and immune system-related disorders.
La présente invention concerne une nouvelle protéine CLC appartenant à la famille des cytokines IL-6. En particulier, l'invention se rapporte à des molécules d'acide nucléiques isolées qui codent la protéine CLC humaine. L'invention concerne également des polypeptides CLC, ainsi que des vecteurs, des cellules hôtes et des procédés de recombinaison permettant de produire ceux-ci. L'invention se rapporte en outre à des procédés de criblage permettant d'identifier des agonistes et des antagonistes de l'activité de la CLC. L'invention concerne enfin des méthodes diagnostiques permettant de déceler les affections cardiaques et les troubles associés au système immunitaire, et à des procédés thérapeutiques permettant de traiter les affections cardiaques et les troubles associés au système immunitaire.
Ruben Steven M.
Shi Yanggu
Human Genome Sciences Inc.
Mbm Intellectual Property Law Llp
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