C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 19/073 (2006.01) A61K 31/70 (2006.01) C07H 19/06 (2006.01)
Patent
CA 2090026
A process for recovering zidovudine or a derivative thereof from a mixture of chemicals comprising zidovudine or a derivative thereof. The process comprises the steps of: (i) reacting zidovudine or a derivative thereof in the mixture with a reagent selected from the group consisting of guanidine, a combination of a base and a guanidine salt, and mixtures thereof, to form a precipitated salt; (ii) acidifying the salt to a pH of less than about 9 to produce substantially pure zidovudine or a derivative thereof; and (iii) recovering the substantially pure zidovudine or a derivative thereof. Zidovudine, also known as AZT, and its derivatives have known anti-viral properties which render them useful in the treatment of, inter alia, AIDS. An aspect of the invention also relates to a novel compound having Formula I: (I) Image wherein X is selected from the group comprising hydrogen, methyl, trifluoromethyl, propenyl, fluoro, chloro, bromo and iodo. A process for producing the compound of Formula I is also provided.
Karimian Khashayar
Radatus Bruno Konrad
Apotex Pharmachem Inc.
Mckinnon Graham J.k.
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