Use of vegf and homologues to treat neuron disorders

Details Use of vegf and homologues to treat neuron disorders Use of vegf and homologues to treat neuron disorders

A - Human Necessities

61

K

A61K 38/18 (2006.01) A61P 25/00 (2006.01) C07K 14/475 (2006.01)

Patent

CA 2654413

The present invention relates to neurological and physiological dysfunction associated with neuron disorders. In particular, the invention relates to the involvement of vascular endothelial growth factor (VEGF) and homologues in the aetiology of motor neuron disorders. The invention further concerns a novel, mutant transgenic mouse (VEGF m/m) with a homozygous deletion in the hypoxia responsive element (HRE) of the VEGF promoter which alters the hypoxic upregulation of VEGF. These mice suffer severe adult onset muscle weakness due to progressive spinal motor neuron degeneration which is reminiscent of amyotrophic lateral sclerosis (ALS) - a fatal disorder with unknown aetiology. Furthermore, the neuropathy of these mice is not caused by vascular defects, but is due to defective VEGF-mediated survival signals to motor neurons. The present invention relates in particular to the isoform VEGF165 which stimulates survival of motor neurons via binding to neuropilin-1, a receptor known to bind semaphorin-3A which is implicated in axon retraction and neuronal death, and the VEGF Receptor-2. The present invention thus relates to the usage of VEGF, in particular VEGF165, for the treatment of neuron disorders and relates, in addition, to the usage of polymorphisms in the VEGF promotor for diagnosing the latter disorders.

Affiliated with

Also associated with

Rating

Use of vegf and homologues to treat neuron disorders does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of vegf and homologues to treat neuron disorders, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of vegf and homologues to treat neuron disorders will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1631931