Mutant forms of meningococcal adp-ribosylating toxin

Details Mutant forms of meningococcal adp-ribosylating toxin Mutant forms of meningococcal adp-ribosylating toxin

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 39/095 (2006.01) A61K 39/395 (2006.01) C07K 14/22 (2006.01) C07K 16/12 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2497279

NMB1343 is an ADP-ribosylating toxin from Neisseria meningitidis. The invention provides a mutant toxin having a substitution at one or more of amino Glu-109, Glu-111 or Glu-120. The mutations(s) is/are preferably Glu to Asp. The protein of the invention preferably has reduced or eliminated ADP- ribosyltransferase and/or NAD-glycohydrolase activity relative to the wild- type protein.

NMB1343 est une toxine ADP-ribosylante tirée de Neisseria meningitidis. La toxine mutante de l'invention est substituée à une ou à plusieurs positions d'acides aminés, à savoir, Glu-109, Glu-111 ou Glu-120. La ou les mutations concernent de préférence Glu à Asp. La protéine de l'invention possède, de préférence, une activité ADP-ribosyltransférase et/ou NAD-glycohydrolase réduite ou éliminée par rapport à la protéine de type sauvage.

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