Somatostatin analogue formulations

Details Somatostatin analogue formulations Somatostatin analogue formulations

A - Human Necessities

61

K

A61K 9/10 (2006.01) A61K 9/06 (2006.01) A61K 9/12 (2006.01) A61K 38/31 (2006.01)

Patent

CA 2594711

The present invention relates to pre-formulations of a low viscosity mixture containing: a) at least one diacyl glycerol; b) at least one phosphatidyl choline; c) at least one oxygen containing organic solvent; d) at least one somatostatin analogue; wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. The formulations are useful for generating depot composition for the controlled release of somatostatin analogues such as octreotide. Methods of treatment comprising the administration of such formulations are also provided, as are pre-filled administration devices and kits containing the formulations.

La présente invention a trait à des préformulations d'un mélange à faible viscosité contenant: a) au moins un diacylglycérol; b) au moins un phosphatidyle choline; c) au moins un solvant organique oxygéné; d'au moins un analogue de somatostatine, ladite pré-formulation formant, ou étant capable de former, au moins une structure à phase cristalline liquide lors d'une mise en contact avec un fluide aqueux. Les formulations sont utiles pour la génération de composition de dépôt pour la libération contrôlée d'analogues de somatostatine tels que l'octréotide. L'invention a également trait à des procédés de traitement comprenant l'administration de telles formulations, ainsi qu'à des dispositifs d'administration préremplis et des trousses contenant des formulations.

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