Neurotonin and use thereof

Details Neurotonin and use thereof Neurotonin and use thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61M 1/34 (2006.01) A61M 1/36 (2006.01) A61P 25/02 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12Q 1/04 (2006.01) G01N 33/15 (2006.01) G01N 33/531 (2006.01) G01N 33/563 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2437873

It is intended to specify a substance causative of hyperexcitability in Isaacs syndrome to thereby establish efficacious diagnostic and therapeutic methods therefor. A specific cDNA is isolated from a nerve cell-origin cDNA library by an immunoscreening technique with the use of the serum of a patient with Isaacs syndrome. The nucleotide sequence of the cDNA is clarified and a novel protein neurotonin is obtained by cloning based on the same. Then the amino acid sequence structure of neurotonin is determined. This novel protein, which is considered as the key factor in Isaacs syndrome, is useful in studies on peripheral nerve disorders and clinical application.

L'invention concerne une substance provoquant l'hyperexcitabilité dans le syndrome d'Isaac, permettant de définir des méthodes diagnostiques et thérapeutiques efficaces. Un ADNc spécifique est isolé d'une bibliothèque d'ADNc de cellules nerveuses à l'aide d'une technique d'immunocriblage, avec l'utilisation du sérum d'un patient souffrant du syndrome d'Isaac. La séquence nucléotidique de l'ADNc est clarifiée et une nouvelle protéine, la neurotonine, est obtenue par clonage basée sur celle-ci. La structure de la séquence d'acides aminés de la neurotonine est ensuite déterminée. Cette nouvelle protéine, considérée comme un facteur clé dans le syndrome d'Isaac, est utilisée dans la recherche sur les troubles nerveux périphériques et ses applications cliniques.

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